Petroleum ether is the petroleum fraction consisting of aliphatic and boiling in the range 35–60 °C, and commonly used as a laboratory solvent. Despite the name, petroleum ether is not an ether.
The naphtha mixtures that are distilled at a lower boiling temperature have a higher volatility and, generally speaking, a higher degree of toxicity than the higher boiling fractions.
Inhalation overexposure causes primarily central nervous system (CNS) effects (headaches, dizziness, nausea, fatigue, and incoordination). In general, the toxicity is more pronounced with petroleum ethers containing higher concentrations of aromatic compounds. n-Hexane causes axonal damage in peripheral nerves.
Skin contact can cause allergic contact dermatitis.
Petroleum-derived distillates have not been shown to be carcinogenic in humans. Petroleum ether degrades rapidly in soil and water.
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